We Drive Groundbreaking Critical Care Research


We Drive Groundbreaking Critical Care Research

Our Passion:

many. We want to shine the light on critical care so that we can find new and innovative ways to monitor, diagnose and treat critically ill and injured patients.

Critical illness and injury is the silent epidemic that affects more than 5.7 million Americans every year. It has an enormous societal and economic toll, yet it is not well understood by


Research Areas

Our research spans the major areas of critical care for maximum impact

Research Areas

Our research spans the major areas of critical care for maximum impact


Acute neurologic injuries in the brain and spinal cord are amongst the hardest injuries to treat. Even when they aren’t fatal, the ability to recover is limited. Each year in the United States, an estimated 1.7 million people sustain a traumatic brain injury, 795,000 suffer a stroke and 17,000 sustain a spinal cord injury. That’s why we’re developing diagnostics, monitors and therapeutics for patients who suffer acute neurologic catastrophes such as traumatic brain injury, hemorrhagic stoke, and acute spinal cord injury.


This severe inflammatory response to infection can lead to multiple organ failure, resulting in permanent disability or death. Affecting more than one million patients a year, sepsis is one of the top 10 causes of death in the United States. Our research aims to enhance the pathophysiologic understanding of sepsis to develop new technologies for ultra-early diagnosis and therapeutic guidance.


Each year in the United States, approximately 325,000 sudden cardiac arrests occur outside the hospital, with a survival rate of only 12%. Our comprehensive approach to understanding the pathophysiology of cardiac arrest and cardiogenic shock guides our development of next generation diagnostic tools and therapeutics.

TRAUMA & Combat Casualty Care

Trauma is the leading cause of death in the United States between the ages of 1 and 46, accounting for 41 million ER visits each year. Trauma patients often require resuscitation, surgery, bleeding control, and infection treatment. That care is made even more difficult on the battlefield, where the most critical phase of care is the period from the time of injury until arrival at a medical treatment facility. Our goal is to develop new technologies for the civilian setting and then tailor them for use by military medical personnel.

Critical Care Life Support

Each year, more people die from critical illness or injury than cancer or heart disease. It is the silent epidemic of our country that poses a huge cost to patients, families, and the healthcare system. While critical illness can impact every body part in a different way, many of our technologies and therapeutics can be adapted to improve outcomes for patients across the board.

Product Portfolio

Licensed and emerging critical care products

Product Portfolio

Licensed and emerging critical care products

Licensed Products

These products were licensed to industry partners through the combined efforts of our Commercialization Coach and the
University of Michigan Office of Tech Transfer.

Emerging Products

MCIRCC has a wide range of products that are ready to be licensed. Are you interested in licensing one of these projects?
Get in touch with us.

Education and Training

Mentoring the next generation of innovators

Education and Training

Mentoring the next generation of innovators

The K12 Career Development Program in Emergency Critical Care Research

With the help of their mentoring team, scholars are able to design their three-year development plan including academic courses, professional development training, and research milestones. Through training in clinical trial design, grant writing, data management, and leadership, scholars will advance their research career with the goal of obtaining individual K or R01 funding by the end of their third year of K12 support.

Thanks to NIH funding, MCIRCC offers a three-year, multidisciplinary training program in emergency critical care research. Scholars may choose mentoring teams led by nationally known senior clinician-scientists in Emergency Medicine, Pulmonary and Critical Care, Neurology, General and Trauma Surgery, Cardiovascular Disease, Biomedical Engineering, and Biostatistics. This gives trainees an understanding of all phases of emergency critical care research.

 Program Co-directors:  David J. Pinsky, M.D.  (U-M Samuel Frankel Cardiovascular Center) and  Robert Neumar, M.D., Ph.D.  (U-M Emergency Medicine)

Program Co-directors: David J. Pinsky, M.D. (U-M Samuel Frankel Cardiovascular Center) and Robert Neumar, M.D., Ph.D. (U-M Emergency Medicine)


  • $100,000 salary (plus benefits)
  • $25,000 supply budget
  • $2,500 travel budget
  • Broad knowledge and training in modern clinical and translational science
  • Coursework to address gaps in scientific training
  • Opportunity to pursue an M.S. in Clinical Research Design and Statistical Analysis (CRDSA)
  • Become an affiliate of MCIRCC, the Cardiovascular Center Clinical Research (C3RG) Group, and other relevant multidisciplinary U-M research centers

Photo by danr13/iStock / Getty Images


Junior faculty from diverse backgrounds with demonstrated commitment to emergency critical care research and innovative approaches to diagnosing, monitoring, and treating patients.

We are currently accepting applications for a flexible start date in summer 2018.

Questions about the program? Contact Denise Poirier or call 734-647-4751.

Photo by RossHelen/iStock / Getty Images

MEET THE 2016 K12 scholars

Cindy Hsu, MD, PhD
Hsu's research is focusing on the use of valproic acid (VPA) to improve outcomes for out-of-hospital cardiac arrest patients.

David Machado-Aranda, MD
Aranda is focusing on the use of gene therapy to treat trauma-related pneumonia and sepsis using an electroporation delivery system.